The global distribution of CCR5 delta 32 polymorphism: role in HIV-1 protection
نویسندگان
چکیده
Background The human immunodeficiency virus type 1 (HIV-1) infection occurs by binding to CD4+ receptor and chemokine receptor 5 (CCR5) or the CXC chemokine receptor (CXCR4). A mutation in the CCR5 gene, 32 base pair deletion consequences a truncated protein that is not expressed on the cell surface. The deletion confers resistance to HIV-1 infection and slows the progression of AIDS in HIV infected individuals. The worldwide distribution of CCR5delta 32 polymorphism was congregated by retrieving the data from literature and genotyping new population samples. A comprehensive resource of frequency data for CCR5delta 32 polymorphism in different population samples was created.
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عنوان ژورنال:
دوره 12 شماره
صفحات -
تاریخ انتشار 2012